Wesam Bazzar
Senior Scientist
Stockholm,Sweden
Summary
Experienced researcher in molecular biology with a focus on cancer biology and therapeutics. With over 9 years of hands-on experience, I have a proven track record in designing, performing, and managing scientific experiments. Expertise in interpreting and analyzing scientific data, as well as presenting and publishing results in peer-reviewed scientific journals. Thrives on new challenges and excels at managing diverse projects within an interdisciplinary environment. Works effectively with competent and focused teams, known for proactive nature, capability, and resourcefulness.
Overview
11
11
years of professional experience
17
17
years of post-secondary education
3
3
Languages
Work History
Senior Scientist / Lab Manager
MyCural Therapeutics AB / Uppsala University
11.2022 - Current
- Managing various tasks and roles effectively within the organizationn. The tasks include:
- Projects and lab management, including organizing meetings, establishing Lab SOPs, safety protocols, handling ethical permits, personal training and supervision.
- Designing and performing in vitro and in vivo experiments for the screening and validation small molecules inhibitors, developed by MyCural, PROTACS, in situ proximity assay (isPLA), as well as animal experimentation using different mouse models.
- Tumor immunology studies using MYC-driven mouse tumor model
- Molecular analysis of in vivo data using various molecular techniques, including but not limited to western blot, siRNA, viral transduction, PCR, immunohistochemistry, isPLA, flow cytometry and In situ sequencing (HybISS)
- Scientific communication, writing and reviewing scientific papers, grant applications and publishing articles in peer-reviewed journals.
- Projects and lab management, students training and supervision
- Authored and co-authored numerous high-impact scientific publications, showcasing the company''s cutting-edge research.
Postdoctoral Researcher
Radiumhemmets Forskningsfonder
07.2021 - 06.2022
- Tumor immunology studies using MYC-driven mouse tumor models. The work included:
- Designing and conducting in vivo experiments using conditional transgenic mouse cancer models, as well as xenograft models.
- Molecular analysis of in vivo data using various molecular techniques, including but not limited to western blot, siRNA, viral transduction, PCR, immunohistochemistry, isPLA, flow cytometry and In situ sequencing (HybISS) and Imaging.
- Writing and reviewing scientific papers, grant applications and publishing articles in peer-reviewed journals and presentations.
- Students teaching, mentoring, training and supervision.
Doctoral Candidate
Karolinska Institutet
09.2014 - 06.2021
- Ph.D studies in tumor biology, senescence and cell biology, focusing on MYC-driven mouse tumor models
- The expertise gained during my work includes:
- Designing and conducting in vivo experiments using conditional transgenic mouse cancer models, as well as xenograft models
- Drug screening and evaluation for new therapeutic strategies for cancer treatment
- Expertise in a wide variety of techniques, including cell culture work, western blot, PCR, immunohistochemistry, siRNA, viral transduction, isPLA and flow cytometry
- Imaging, histopathological and molecular analysis of tumor samples
- Writing and reviewing scientific papers, grant applications and publishing articles in peer-reviewed journals
- - Scientific communication, scientific presentations, teaching, mentoring and supervision
Education
ICH Good Clinical Practice E6 - undefined
Radiumhemmets Forskningsfonder
07.2021 - 05.2022
Doctorate of Tumor Biology, PhD - undefined
Karolinska Institute
Stockholm 09.2014 - 05.2021
Master's in Medical Sciences - Molecular Medicine
Uppsala University
Uppsala 01.2011 - 05.2013
Master's in biology - Medical Molecular Biology
University of Örebro
Örebro 01.2009 - 05.2011
Bachelors in Genetics engineering and Biotechnology - undefined
Jordan University of Science and Technology
Irbid 01.2004 - 05.2008
Skills
Molecular and Cell biology
Tumor biology and immunology
Scientific communications
Preclinical research
Drug screening
IHC/IF
qPCR
Viral transduction
Animal study design and experimentation
Data analysis
Expression systems
Mammalian cell culture
Bioimaging Techniques
Western blot
In situ proximity ligation assay (isPLA)
Flow cytometry analysis
Cell toxicity assays
Problem-solving
Project and Lab management
Teaching and Supervision
H Index
6
Orcid Id
0009-0001-6892-8337
Citations
256
Publications
- MYCN Amplification Is Associated with Reduced Expression of Genes Encoding γ-Secretase Complex and NOTCH Signaling Components in Neuroblastoma, Agarwal P, Glowacka A, Mahmoud L, Bazzar W, Larsson LG, Alzrigat M, Int J Mol Sci, 05/02/23, 24, 9, 8141, 10.3390/ijms24098141, 37175848
- MYCMI-7: A Small MYC-Binding Compound that Inhibits MYC: MAX Interaction and Tumor Growth in a MYC-Dependent Manner, Castell A, Yan Q, Fawkner K, Bazzar W, Zhang F, Wickström M, Alzrigat M, Franco M, Krona C, Cameron DP, Dyberg C, Olsen TK, Verschut V, Schmidt L, Lim SY, Mahmoud L, Hydbring P, Lehmann S, Baranello L, Nelander S, Johnsen JI, Larsson LG, Cancer Res Commun, 03/31/22, 2, 3, 182-201, 10.1158/2767-9764.CRC-21-0019, 36874405
- Methods to Study Myc-Regulated Cellular Senescence: An Update, Zhang F, Bazzar W, Alzrigat M, Larsson LG, Methods Mol Biol, 2318, 241-254, 10.1007/978-1-0716-1476-1_12, 34019294
- Pharmacological inactivation of CDK2 inhibits MYC/BCL-XL-driven leukemia in vivo through induction of cellular senescence, Bazzar W, Bocci M, Hejll E, Högqvist Tabor V, Hydbring P, Grandien A, Alzrigat M, Larsson LG, Cell Cycle, 01/01/21, 20, 1, 23-38, 10.1080/15384101.2020.1855740, 33356836
- A selective high affinity MYC-binding compound inhibits MYC:MAX interaction and MYC-dependent tumor cell proliferation, Castell A, Yan Q, Fawkner K, Hydbring P, Zhang F, Verschut V, Franco M, Zakaria SM, Bazzar W, Goodwin J, Zinzalla G, Larsson LG, Sci Rep, 07/03/18, 8, 1, 10064, 10.1038/s41598-018-28107-4, 29968736
- Elevated expression of the C-type lectin CD93 in the glioblastoma vasculature regulates cytoskeletal rearrangements that enhance vessel function and reduce host survival, Langenkamp E, Zhang L, Lugano R, Huang H, Elhassan TE, Georganaki M, Bazzar W, Lööf J, Trendelenburg G, Essand M, Pontén F, Smits A, Dimberg A, Cancer Res, 11/01/15, 75, 21, 4504-16, 10.1158/0008-5472.CAN-14-3636, 26363010
Timeline
Senior Scientist / Lab Manager
MyCural Therapeutics AB / Uppsala University
11.2022 - Current
Postdoctoral Researcher
Radiumhemmets Forskningsfonder
07.2021 - 06.2022
ICH Good Clinical Practice E6 - undefined
Radiumhemmets Forskningsfonder
07.2021 - 05.2022
Doctoral Candidate
Karolinska Institutet
09.2014 - 06.2021
Doctorate of Tumor Biology, PhD - undefined
Karolinska Institute
09.2014 - 05.2021
Master's in Medical Sciences - Molecular Medicine
Uppsala University
01.2011 - 05.2013
Master's in biology - Medical Molecular Biology
University of Örebro
01.2009 - 05.2011
Bachelors in Genetics engineering and Biotechnology - undefined
Jordan University of Science and Technology
01.2004 - 05.2008