Niyaz Yoosuf
Director, Computational Biology
Lund
Summary
Highly motivated computational biologist with 15+ years of strong research experience in big data analysis and machine learning. Diligent and independent individual with in-depth knowledge of clinical studies and high dimensional data with documented publication record in peer-reviewed journals.
Overview
16
16
years of professional experience
3
3
years of post-secondary education
5
5
Languages
Work History
Director Computational Biology
BioInvent International AB
Lund
02.2022 - Current
- Spearheaded successful computational biology programs for immunotherapy based preclinical studies.
- Increased understanding of drug targets by streamlining projects and implementing cost-saving experiments.
- Developed a core facility for high dimensional data analyses
- Enhanced team collaboration through regular communication, goal setting, and performance evaluations.
Co-Founder
Queo Health
10.2022 - Current
- Implemented data-driven decision-making to optimize business performance and drive growth.
- Lead team for successfully designing machine learning algorithms for data analytics and visualization
- Established and maintained strong relationships with customers, vendors and strategic partners.
Senior Postdoctoral Researcher - Pharmacogenomics
Karolinska Institute
09.2017 - 03.2021
- Biomarker evaluation: Managed cross-functional teams, analyzed clinical, transcriptome, proteome and flow cytometry data. Integrative analysis of multi-omics data and interpreted statistical results for treatment response of rheumatoid arthritis patients
- Personalized Medicine: Performed Unsupervised and Supervised clustering of big multi-omics data to predict anti-TNF treatment response
- Industrial collaboration: Led projects, analyzed big data and worked with Pfizer's multidisciplinary team and delivered industrial research goals
- Bioinformatics: Developed data processing pipelines for RNA-Seq data, CAGE, TCR-sequencing and provided bioinformatics/Linux/Server support to research group members
- Teaching: Taught doctoral course "Basic Bioinformatics" for two years, co-supervised master's student thesis project and trained multiple Postdocs and doctoral students in Bioinformatics
- Published research results in peer-reviewed journals and presented at seminars and meetings
Consultant Intern - Health Outcome Research
Schain Research
01.2021 - 03.2021
- Use of real-world evidence data to support regulatory decision-making for pharmaceutical companies
- Wrote methodological and analytical reports tailored to specific project and client needs and created Statistical Analysis Plan (SAP).
- Applied statistical methods to rare genetic condition using Real-World Data (RWD) from National Swedish Patient Registries.
- Health economics analysis and measured economic burden of disease
- Analyzed, interpreted and presented research findings to Blue bird biotech company
Postdoctoral Researcher - Spatial Transcriptomics
Karolinska Institute
Stockholm
07.2014 - 06.2017
- Developed Cap analysis gene expression (CAGE) analysis pipeline
- Analyzed Spatial Transcriptomics (ST) data and applied machine learning methods to predict cell types in human breast cancer tissue sections and mouse olfactory bulb samples
- Supervised master's student project.
- Authored professional scientific papers for publishing in peer-reviewed journals.
Project Assistant - Evolutionary Biology
Indian Institute of Technology, Madras
07.2008 - 08.2010
- Evolutionary Biology: Run project on phylogenetic analysis of polysaccharide lyase 8 family
- Performed comparative genomics, phylogenomics and structural analysis of proteins
Education
Doctor of Philosophy - Bioinformatics
Aix-Marseille University
Marseille, France 11.2010 - 12.2013
Master of Science - Bioinformatics
University of Madras
Chennai, India 07.2006 - 2008.05
Bachelor of Science - Bioinformatics
Manonmaniam Sundarnar University
Tirunelveli, India 07.2003 - 2006.05
Skills
Clinical Research/Biomarker Discovery
undefinedComputer Skills
- Operating system: Linux, Mac OSX, Windows
- Programming languages: Python, SQL, bash
- Statistical Programming: R/Bioconductor
- Server management and support
Reproducible research
- GitHub: https://github.com/niyaznihmath
- R Markdown
Publications
Pubmed link below
https://pubmed.ncbi.nlm.nih.gov/?term=niyaz+yoosuf&sort=date
Major Bioinformatics Skills
- High-throughput data analysis of genomics, transcriptomics (RNA-Seq, scRNA-Seq, CAGE), microarray analysis, proteomics and flow cytometry
- Experience with stratifying clinical data & identifying biomarkers
- T-cell repertoire sequencing and analysis
- Spatial transcriptomics analysis
- Machine learning, Unsupervised and supervised learning
- Statistical analysis for Real World Evidence data
- Genome assembly, genome annotation, Evolutionary analysis
Timeline
Co-Founder
Queo Health
10.2022 - Current
Director Computational Biology
BioInvent International AB
02.2022 - Current
Consultant Intern - Health Outcome Research
Schain Research
01.2021 - 03.2021
Senior Postdoctoral Researcher - Pharmacogenomics
Karolinska Institute
09.2017 - 03.2021
Postdoctoral Researcher - Spatial Transcriptomics
Karolinska Institute
07.2014 - 06.2017
Doctor of Philosophy - Bioinformatics
Aix-Marseille University
11.2010 - 12.2013
Project Assistant - Evolutionary Biology
Indian Institute of Technology, Madras
07.2008 - 08.2010
Master of Science - Bioinformatics
University of Madras
07.2006 - 2008.05
Bachelor of Science - Bioinformatics
Manonmaniam Sundarnar University
07.2003 - 2006.05
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