Krishna Sreenivasan
Göteborg
Summary
Accomplished Senior Research Scientist with over ten years of experience across academia and industry, including impactful contributions at AstraZeneca. Expert in assay development, advanced screening technologies, and oligonucleotide safety evaluation, with a proven track record in driving successful drug discovery projects from conception to execution. Recognized for mentoring and developing junior scientists, fostering collaborative, high-performing teams, and championing innovation through strategic problem-solving and cross-functional leadership.
Overview
18
18
years of professional experience
1
1
Certification
Work History
Senior Research Scientist
AstraZeneca
Gothenburg, Sweden
12.2022 - Current
- Mentored and guided junior scientists, fostering skill development, independence, and higher project success rates.
- Provided expert consultation for evaluating new technologies and companies to enhance platform capabilities.
- Designed and optimized screening pipelines for oligonucleotide modalities in targeted drug delivery.
- Established and validated assays to evaluate oligonucleotide safety and effectively identify toxic candidates.
- Led and collaborated on cross-functional teams to deliver innovative projects and publish patents.
- Acted as a liaison between discovery science and bioscience teams, ensuring strategic project alignment and communication.
- Developed and implemented advanced assay development and automated high-throughput screening methodologies.
- Managed and operated state-of-the-art imaging and laboratory instrumentation (e.g., Yokagawa, Incucyte, Echo, Certus Flex, Bravo, Multidrop, Bluewasher).
- Created and optimized automated workflows for advanced cell models, including iPSC-derived systems.
- Project management experience, including resource allocation, milestone tracking, and team supervision.
- Conducted complex data analysis, interpretation, and reporting for multidisciplinary audiences.
- Improved laboratory workflows, ensuring compliance with data integrity, regulatory, and safety standards.
- Fostered a collaborative and supportive team environment focused on scientific excellence and continuous learning.
Senior Scientific Consultant
Innocent Meat
Rostock, Germany
05.2022 - 05.2024
- Served as expert scientific consultant, guiding sustainable cell-based meat innovations.
- Spearheaded scientific assessment and strategy to enhance product development processes.
- Conducted high-level analysis of muscle biology to drive research and innovation.
- Mentored 3-4 scientists in study design, optimization, and implementation.
- Collaborated with cross-functional teams to align scientific goals with business objectives.
- Fostered continuous learning culture among junior scientists through mentorship.
Doctoral Fellow
Max Planck Institute for Heart and Lung Research
Bad Nauheim, Germany
10.2011 - 05.2017
- Expert in assay development, tissue regeneration, primary stem cell isolation, maintenance, and differentiation.
- Initiated collaboration between CNIC, Spain, and MPI-HLR, Germany on understanding how striated muscle identity is established during cardiac development and diseases (Gómez-Del Arco et al., 2016) (Collaboration).
- Established an assay to perform lentiviral-based RNAi screens to identify chromatin-modifying enzymes and epigenetic regulators of muscle stem cell self-renewal and differentiation (Sreenivasan K et al., 2017) (Project Lead).
- Established an internal collaboration to elucidate the role of Interleukin-6 (IL-6) cytokine-oncostatin M (OSM) signaling in mouse and human (Adrian-Segarra, J.M et al., 2018) (Collaboration).
- Established an industry-led collaboration with Boehringer Ingelheim to perform high-content screening on muscle regulators to identify factors regulating aging associated with muscle pathologies (Industry Collaboration).
- Demonstrated exceptional leadership qualities while managing multiple projects simultaneously under tight deadlines without sacrificing quality or accuracy.
Research Scientist/Post Doctoral Fellow
Max Planck Institute for Heart and Lung Research
Bad Nauheim, Germany
09.2011 - 05.2017
- Mentored 5-6 junior scientists and technical assistants, fostering professional development and team capabilities.
- Assisted in writing grant proposals for additional funding opportunities for ongoing projects.
- Led projects investigating necroptosis to promote cell death and enhance immune response against cancer (2020-2022).
- Identified necroptosis role in lung regeneration and pulmonary fibrotic diseases as project lead (2021-2022).
- Investigated paracrine signaling via exosomes in cancer progression and biomarker identification (2020-2022).
- Discovered the epigenetic function in cardiac lineage commitment and stem cell fidelity (Sreenivasan et al., 2021).
- Explored interactions between cell death pathways influencing muscle stem cell plasticity and regeneration (Sreenivasan et al., 2020).
- Delineated cancer stem cells' contributions to rhabdomyosarcoma tumorigenesis (Preussner, J., et al., 2018).
- Served as imaging expert and trainer; developed methodologies for data analysis and interpretation.
Research Associate
Max Planck Institute for Biochemistry
Munich, Germany
01.2008 - 10.2011
- Investigated DNA repair proteins' role in chromosome segregation defects, contributing to aneuploidy and tumorigenesis.
- Established synthetic lethal screening pipeline to evaluate genetic compensation during chromosome segregation.
- Leveraged expertise in molecular cloning techniques, including quantitative PCR and Western blot analysis.
- Conducted immunoassays such as ELISA and performed RNA/DNA/protein extraction and immunoprecipitation.
Junior Research Fellow
National Center for Biological Sciences (NCBS)
Bengaluru, India
07.2007 - 12.2008
- Analyzed impact of endosomal tracking proteins via a functional RNAi screening process in Drosophila.
Education
Ph.D. - Cell Biology
International Max Planck Research School (IMPRS)
Bad Nauheim, Germany05.2017
Master of Science - Industrial Microbiology
University of Madras
Chennai, India12.2008
Bachelor of Science - Microbiology
Bharathidasan University
Tiruchirappalli, India05.2005
Skills
- Leadership and mentoring
- Scientific communication
- Assay development expertise
- Biomarker discovery specialist
- Flow cytometry proficiency
- Animal handling certification
- RNA sequencing and proteomics
- Immunological assays experience
- Cancer biology background
- Drug discovery involvement
- Complex problem solving
Selected Publications
Sreenivasan K, et al. "Attenuated epigenetic suppression of muscle stem cell necroptosis..." Cell Reports. 2020.
Sreenivasan K, et al. "CHD4 ensures stem cell lineage fidelity during skeletal muscle regeneration." Stem Cell Reports. 2021.
Gómez-del Arco P, Sreenivasan K, et al. "The chromatin remodeling complex Chd4/NuRD controls striated muscle identity..." Cell Metabolism. 2016.
Full publication list: Google Scholar: Krishnamoorthy Sreenivasan
Certification
- Basic Good Manufacturing Practices (GMP) 2021
- 7 Week Fast Forward Implementation Program (Time and Project Management) 2021
- FELASA A and D (Animal Handling and Surgery) 2014
- Introduction to GCP 2014
- Advanced flow cytometry training 2012
Languages
Tamil
First Language
English
Proficient (C2)
C2
German
Elementary (A2)
A2
Swedish
Beginner
A1
Volunteer Experience
PhD and Post-doctoral representative, Max Planck Institute for Heart and Lung Research, 2013-2022
Organizing yearly soft skill workshops and retreats for PhD and postdoctoral students.
Acting as a liaison between students and faculty to solve any pertaining conflicts of interest, establishing a post-doctoral association within the institute, and providing a platform for career building
Organizing career development events in close collaboration with the Max Planck Academy and the Max Planck Society, PostdocNet.
Awards
Best Poster award at the German Stem Cell Network (GSCN) conference (2016)
Boehringer Ingelheim Fond Travel Grant (05/2008 - 06/2008)
University Rank holder both during Bachelors and Masters (2002 - 2007)
Indian Institute of Technology, Madras (IIT-M) summer internship (05/2006 - 07/2006)
References
References available upon request.
Timeline
Senior Research Scientist
AstraZeneca
12.2022 - Current
Senior Scientific Consultant
Innocent Meat
05.2022 - 05.2024
Doctoral Fellow
Max Planck Institute for Heart and Lung Research
10.2011 - 05.2017
Research Scientist/Post Doctoral Fellow
Max Planck Institute for Heart and Lung Research
09.2011 - 05.2017
Research Associate
Max Planck Institute for Biochemistry
01.2008 - 10.2011
Junior Research Fellow
National Center for Biological Sciences (NCBS)
07.2007 - 12.2008
Ph.D. - Cell Biology
International Max Planck Research School (IMPRS)
Master of Science - Industrial Microbiology
University of Madras
Bachelor of Science - Microbiology
Bharathidasan University
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